PARP1 and neoplasm: For example, while the canonical role of PARP is through the DNA damage repair pathway, PARP also plays a role in various networks including tumor-promoting inflammation, cell cycle checkpoint regulation, senescence, angiogenesis, epithelial-mesenchymal transition (EMT), PARylation and remodeling of chromatin during transcription, and programmed cell death and metastasis [14, 127–130].