While defects in HR pathways signify opportunities for synthetic lethality, there is a push to look beyond BRCA mutational status to assess HR dysfunction, especially since only 15% of ovarian epithelial cancers are deficient in HR due to mutations of BRCA1/2 [22, 23] and only 5–10% of breast and ovarian cancers are associated with BRCA germline mutation [24]. Here, BRCA1 is linked to ovarian carcinoma.