ITCH protein promotes the degradation of phosphorylated Dvl2, which is an important regulator for Wnt/β-catenin signaling activation [21]. cir-ITCH, acting as a sponge of oncogenic miRNAs, can competitively inhibit these miRNAs' bind to ITCH and thus indirectly suppresses the activation of Wnt/β-catenin signaling in esophageal squamous cell carcinoma [16]. This evidence concerns the gene DVL2 and esophageal squamous cell carcinoma.