As sponge of oncogenic miR-7, miR-17, and miR-214, cir-ITCH increases the level of ITCH and thus indirectly inhibits the activation of Wnt/β-catenin pathway; these effects finally result in the suppression of esophageal squamous cell carcinoma [16] and colorectal cancer [15]. This evidence concerns the gene ITCH and colorectal cancer.