ITCH and neoplasm: As shown in Table 1, cir-ITCH expression in lung cancer tissues was significantly associated with age (p = 0.0076); however, it is not correlated with other clinical characteristics including sex (p = 0.9704), family history (p = 0.8437), smoking (p = 0.1713), drinking (p = 0.1568), tumor type (p = 0.9183), and TNM stage (p = 0.2531) in lung cancer patients.