TBX1 and 22q11.2 deletion syndrome: For example, TBX1 haploinsufficiency resulting from 22q11.2 deletions is thought to cause cardiac and pharyngeal apparatus defects in the common cardiovelofacial/Di George syndrome [75], and Tbx1 mutations phenocopy 22q11-induced defects in mouse models [76,77,78], whereas the etiology of this syndrome is rather complex, there is mounting evidence that multiple defects arise from alteration of TBX1 function in cardiopharyngeal mesoderm progenitors of early embryos [79,80,81,82].