Investigations on experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis indeed have rendered evidence that the DC‐HIL/SD‐4 pathway regulates autoimmune responses by mediating the T‐cell suppressor function of CD11b(+)Gr‐1(+) myeloid‐derived suppressor cells (MDSC) 47. Here, ITGAM is linked to multiple sclerosis.