Disorders leading to GH as a consequence of systemic disease include sarcoidosis, Crohn's disease, pyoderma gangrenosum, syphilis, tuberculosis, pituitary adenomas, Langerhans cell histiocytosis, granulomatosis with polyangiitis, and foreign body granulomas secondary to Rathke's cleft cyst rupture. This evidence concerns the gene GH1 and pyoderma gangrenosum.