Disorders leading to GH as a consequence of systemic disease include sarcoidosis, Crohn's disease, pyoderma gangrenosum, syphilis, tuberculosis, pituitary adenomas, Langerhans cell histiocytosis, granulomatosis with polyangiitis, and foreign body granulomas secondary to Rathke's cleft cyst rupture. The gene discussed is GH1; the disease is Langerhans cell histiocytosis.