GH1 and central nervous system cyst: Disorders leading to GH as a consequence of systemic disease include sarcoidosis, Crohn's disease, pyoderma gangrenosum, syphilis, tuberculosis, pituitary adenomas, Langerhans cell histiocytosis, granulomatosis with polyangiitis, and foreign body granulomas secondary to Rathke's cleft cyst rupture.