Indeed UCP3-knockout hearts generated more reactive oxygen species (ROS) than WT hearts during ischemia/reperfusion and the pretreatment of UCP3-knockout hearts with the pharmacological uncoupling agent such as carbonyl cyanide p-(trifluoromethoxy)-phenylhydrazone (FCCP) improved postischemic functional recovery [18]. The gene discussed is UCP3; the disease is ischemia.