In addition, FGFR1 [32], FGFR2 [33], CACNA1C [34], GNG12 [35], MAP3K8 [36], and Nf1 [37] are involved in the differentiation potential of MSCs, indicating that some differences in the differentiation capacities of RA and HD SMSCs might exist. This evidence concerns the gene GNG12 and rheumatoid arthritis.