A risk of dyslipidemia was 1.6-fold higher in subjects showing this haplotype (OR 1.640, 95% CI 1.151–2.338, P = 0.006). VDR rs1544410 and VDR rs2228570 showed also a significant epistatic interaction (FDR-adjusted P = 0.027) (Supplementary Table 12). Here, VDR is linked to metabolic syndrome.