PTGS2 and brain ischemia: Cox-2 is also an important contributor to the progression of brain injury after cerebral ischemia, as studies have shown that the pharmacological or genetic silencing of Cox-2 results in decreased brain damage, while the overexpression of Cox-2 increases the brain’s vulnerability to ischemic injury (Nogawa et al., 1997; Dore et al., 2003; Sasaki et al., 2004; Kunz et al., 2007).