It has been described that Th1-type immunity is characterized by activation of CD4+ T cells and secretion of IFN-γ and IL-12 which in turn stimulate a protective cell-mediated immune response to fungal infections, including P. brasiliensis [66, 67], while Th-17 pattern appears to be the major contributor to both the initiation and control of the inflammatory immune response to fungal infections [67]. This evidence concerns the gene IFNG and fungal infectious disease.