Some authors have associated the prevalence of eosinophils with a Th2 pattern which is less efficient in controlling P. brasiliensis infection, as indicated by Mamoni et al. [59] who stated that eosinophilia and a Th2 pattern of cytokine expression, as well as IgE, IgG4, and IgA, are present in patients with the juvenile and multifocal adult forms of PCM. The gene discussed is IGHE; the disease is paracoccidioidomycosis.