In vitro studies evidenced another possible mechanism responsible for these data: the expression of CEACAM1-L in melanocytic cells (CEACAM1 negative MEL6 melanocytic cell line) and melanoma cell (CEACAM1 negative MV3 melanoma cell line) increased the invasive and the migratory properties of melanocytic and melanoma cells, by interaction with integrins [43]. The gene discussed is CEACAM1; the disease is melanoma.