Kluger and colleagues proposed a multiplex, plasma-based protein biomarker panel that included CEACAM, ICAM-1 (intercellular adhesion molecule 1), osteopontin, MIA (melanoma inhibitory activity), GDF-15 (growth differentiation factor 15), TIMP-1 (tissue inhibitor of metalloproteinase 1), and S100B. This evidence concerns the gene TIMP1 and melanoma.