Mechanisms by which CEACAM1 interacts with melanoma biology are incompletely elucidated. In vitro studies revealed the relation between CEACAM1 expression and melanoma cells behavior; increased expression of CEACAM1 in melanoma cell lines amplified the invading capacity of these cells; downregulation of CEACAM1 expression in melanoma cells decreased the expansion ability of cells. This evidence concerns the gene CEACAM1 and melanoma.