The development of cSCC is influenced by many other modifications induced by UV radiation such as the presence of melanocortin-1 receptor (associated with fair skin and red hair) which represents a risk factor for developing cSCC as well as melanoma [109], increased telomerase activity which may protect cSCC from apoptosis [110], and mutations of NOTCH genes, which are tumor suppressor genes identified in 75% of patients diagnosed with cSCC [56]. The gene discussed is MC1R; the disease is skin squamous cell carcinoma.