In addition, it was reported that rs713041 in GPx4 was associated with idiopathic recurrent miscarriage and it could be regarded as a predictor of cerebral stroke in Russian patients with essential hypertension, while Xiao et al. stated that both SNPs were related to the development of Kashin-Beck disease in the Chinese population19, 36, 37. Here, GPX4 is linked to Miscarriage.