The frequencies of CD4+ CD25+ Foxp3+ (Fig. 2B) and CD4+ CD25+ CD127− cells (Fig. 2C) in the spleens from mice with DSS‐induced colitis were significantly down‐regulated by wogonin (100 mg/kg) treatment, compared with those in the solvent and DSS/solvent groups. The gene discussed is CD4; the disease is colitis.