PALLD and neoplasm: Interestingly, tumours showed inverse expression levels of Palladin and the miRNAs: Palladin mRNA expression was high only in groups treated with hydrogels embedded with targeted nanoparticles carrying control miRNA and exhibited a approximately fivefold decrease following treatment with miR-96 or miR-182, which was not weakened by the intercalation of cisplatin to the miRNA-nanoparticles (Fig. 6f).