In addition to genetic mutations, BAFF and APRIL also activate the non-canonical NFκB pathway in mature B-cells and myeloma cells.48 In this context, future studies ought to investigate the possible role of autoregulatory RelB control in transducing BAFF signal in processes requiring prolonged NFκB activity, such as B-cell differentiation and myeloma cell survival. Here, NFKB1 is linked to plasma cell myeloma.