The proposed autoregulatory control is consistent to the previous finding demonstrating heightened RelB mRNA levels in myeloma patients harboring mutations in non-canonical NFκB module.22 Our observation that high RelB level is correlated with augmented expression of pro-survival factors and resistance of patients to therapy also indicated possible involvement of autoregulatory RelB control in multiple myeloma (Figure 7). This evidence concerns the gene RELB and AL amyloidosis.