This major function is confirmed by the predominant decrease in colony‐forming cells following its gene silencing compared to those of PRUNE2 and CHI3L1. These datas concerning KLRC3 involvement in glioblastoma aggressiveness are supported by the decrease in tumour growth after shKLRC3 cells engraftment in vivo compared to control cells. Here, PRUNE2 is linked to glioblastoma.