EGFR and central nervous system cancer: In addition, we also highlighted the suppressive effects of GnT-III on regulating the site-11 N-glycan-mediated EGFR-α5 complex formation, which may be a plausible molecular mechanism involved in GnT-III-mediated tumorigenesis in several tumors such as human hepatomas, glioma, and ovarian cancers54, 55, 56.