LRRK2 and Parkinson disease: Our data showed that the differentiating cells derived from the LRRK2 G2019S NSCs were more complex at all the time points analyzed (at day1: 1.26 ± 0.07 for WT culture and 1.70 ± 0.11 for PD culture, p = 0.0307; at day 3: 1.53 ± 0.12 for WT culture and 2.2 ± 0.09 for PD culture in the proximal regions, p = 0.002; at day 5: 1.11 ± 0.03 for WT culture and 1.77 ± 0.12 for PD culture at proximal and distant regions from the soma p = 0.001 and p = 0.03, respectively (Fig. 4E)).