Kaplan–Meier survival analysis showed that apart from PSA (P < 0.001), Gleason score (P = 0.001), and pathologic stage (P = 0.005), the genotypes of rs351855 also significant influenced the BCR-free survival of patients with prostate cancer (P = 0.001, Fig. 1); by contrast, rs1966265 and rs2011077 did not influence the survival (P = 0.355 and P = 0.188, respectively, Supplemental Fig. 1). The gene discussed is KLK3; the disease is Familial prostate cancer.