BMAL1 and Anxiety: Whereas littermate WT mice (Bmal1fl/flEmx1+/+) reproduced the circadian variations in anxiety-like behaviors of WT mice (Fig. 1) at CT2 (early subjective day) and CT14 (early subjective night), anxiety-like behaviors remained high in Bmal1 cKO mice both during the day and night at levels comparable to the peak levels in littermate WT mice (Fig. 2d–h).