In both the EPM and OF tests, Scop cKO mice failed to express circadian changes in anxiety-like behaviors: While littermate WT mice (Scopfl/flEmx1+/+) reproduced the circadian variations in anxiety-like behaviors of WT mice (Fig. 1) between CT2 (day) and CT14 (night), anxiety-like behaviors remained constantly low at both CTs in Scop cKO mice (Fig. 4b–f), a phenotype distinct from that of Bmal1 cKO mice (Fig. 2). The gene discussed is BMAL1; the disease is Anxiety.