ALB and major depressive disorder: A forward selection model, based on a total of 1006 patients with 360 (36%) reporting poor quality of life showed that following adjustment for the effects of age at presentation, as well as gender, albumin level (as a marker for advanced disease), disease duration, and UDCA response, identified the symptom domains of social, fatigue, anxiety and depression as important predictors of poor perceived quality of life (in descending order) [Table 4].