FOXA1 and breast cancer: Notably, breast cancer-associated SNPs are enriched for FOXA1 binding17 and several studies have linked cooperative binding of FOXA1, ER, and OCT1 to increased gene transcription.18, 19 Consistent with our eQTL data, it is tempting to speculate that in specific ER+ cell subtypes and/or conditions, rs10941679 alters FOXA1 affinity and OCT1 recruitment leading to target gene activation.