KRIT1 and cerebral cavernous malformation: Indeed, consistent with a potential role for inflammatory processes in CCM disease pathogenesis, mice heterozygous for the deletion of the KRIT1 gene (KRIT1+/−) exhibit an enhanced sensitivity to inflammatory stimuli (Corr et al., 2012), and there is evidence that inflammatory response occurs in CCM lesions (Shenkar et al., 2007, Shi et al., 2009) (see Sections 4, 5 and 7).