Dysregulation of several genes previously associated with canine diffuse large B-cell lymphoma in the NF-kB signaling and B-cell receptor signaling pathways shared conserved expression in CLBL-1 including the following: KRAS, NRAS, PIK3R5, PLCG2, TGFBR2, TNFAIP3, TRADD, BCL2A1, CAMK2D, NFATC2 [48], BUB1B, PRKCD, CD83, CXCL13, CD36, IL8, IL2, CD40LG, LCK, LTBR, and TNFSF11 [21]. The gene discussed is PIK3R5; the disease is diffuse large B-cell lymphoma.