In patients carrying ADAMTS18 mutations that cause eye disease, one reported mutation resulted in premature termination of mRNA at codon 356 and was predicted to result in a null phenotype, whereas the other mutations were more at the C-terminal in the cysteine-rich region of the protease or TSRs (Peluso et al., 2013; Chandra et al., 2014). Here, ADAMTS18 is linked to eye disorder.