We and others have demonstrated the anti-inflammatory and anti-erosive capacities of TNF blockade on both local and systemic bone destruction in the hTNFtg arthritis model (Binder et al., 2013; Keffer, et al., 1991; Redlich, et al., 2004; Shealy et al., 2002; Zwerina et al., 2004). The gene discussed is TNF; the disease is arthritic joint disease.