Importantly, though UTI had little effect on phosphorylation of p-38, various concentration of UTI (500 or 5000 units/ml) decreased the phosphorylation of I-κB, ERK (1/2), MEK and JNK in a dose-dependent manner in LPS/PMMA-stimulated Raw264.7 cells. This evidence concerns the gene MAPK8 and bacterial urinary tract infection.