Recently, Fanconi Anemia (FA) Fancd2−/− (129/Sv) mice with cytokeratin 14 (K14) promoter controlled production of E7 onco-protein of HPV derived from genetic cross with K14E7 mice (FVB/n) were shown to be susceptible to both chemical carcinogen induced oral squamous cell tumors, and estrogen pellet induced cervix cancers [26]. This evidence concerns the gene FANCD2 and squamous cell neoplasm.