While LTBMC derived K14E7 Fancd2−/− and K14E7 Fancd2+/+ cell lines showed expression of CK14 and its linked E7 oncogene protein in both marrow stromal and hematopoietic cells, only hematopoietic cell lines from the former generated malignant plasmacytoma cell lines in vitro. Here, FANCD2 is linked to plasmacytoma.