Cells from the same K14E7 Fancd2−/− clone 1 cell line injected I.V. at 1 × 106 cells in 100 μl formed multiple lung, liver, and soft tissue metastases, replaced the bone marrow with tumor cells, and produced peripheral blood leukemia with Ig kappa and lambda positive cells (not shown). This evidence concerns the gene FANCD2 and leukemia.