We confirmed that K14E7 Fancd2−/− mice treated with oral 4-NQO developed squamous cell tumors of the oral cavity and esophagus, but we saw no detectable effect of oral 4-NQO treatment of these tumor bearing mice on malignant transformation of their explanted bone marrow in LTBMCs. This evidence concerns the gene FANCD2 and squamous cell neoplasm.