In IFN-γ-stimulated tumor cells exposed to a DUOX2-specific siRNA, however, in addition to a lack of DUOX2 expression and decreased HIF-1α expression, we observed diminished ERK and S6 activation (compare lane 4 to lane 2) as well as no phosphorylation of 4E-BP1. The gene discussed is HIF1A; the disease is neoplasm.