HIF1A and neoplasm: When BxPC-3 tumor cells were treated for 8 h with IFN-γ alone or in combination with PEG-catalase (to increase intracellular peroxide detoxifying capacity) [36, 37], the induction of HIF-1α by IFN-γ was decreased in a PEG-catalase concentration-dependent fashion (Figure 2G).