CXCR2 and neoplasm: In malignancies, tumor associated macrophages (TAMs) have been traditionally considered to belong to the polarized M2 phenotype and can be identified using varies markers, such as CD163, CD23, IL-10, CXCR2 and others [40] M2-type TAMs decrease response to chemotherapy and radiotherapy, impair T cell infiltration and function, and promote immune evasion and tumor progression [40, 41].