A tumour suppressive role would also be consistent with studies demonstrating that SASH1 depletion increases lung cancer cell line viability, proliferation and migration [3, 6–8], and several recent studies demonstrated that it opposes mesenchymal differentiation and invasive cell behaviour in hepatocarcinoma, thyroid and ovarian cancer cell lines [9–11]. This evidence concerns the gene SASH1 and lung carcinoma.