SIRT2 and neoplasm: Examination of the lungs in a cohort of untreated Sirt2-/--KrasG12D mice as well as KrasG12D and Sirt2-/--KrasG12D mice 4 months after exposure to adenoCRE revealed that Sirt2-null mice had a significantly greater number of tumor lesions in the lungs (Figure 2A, 2B), as well as larger tumor area (Figure 2C), than KrasG12D mice.