KRAS and lung adenocarcinoma: To determine the role of SIRT2 in KRAS-dependent lung adenocarcinoma, the well-established LSL-KrasG12D knock-in mouse model was crossed with Sirt2-/- mice to generate Sirt2+/+;LSL-KrasG12D and Sirt2-/-;LSL-KrasG12D mice (referred to here as KrasG12D and Sirt2-/--KrasG12D mice, respectively) followed by intranasal administration of adenoviral Cre (adenoCRE) to induce mtKras expression in the lungs [15].