CMA1 and Cirrhosis: Moreover, hepatocytes of normal human liver host chymase at the periphery of lobules, but hepatocytes of regenerative nodules of cirrhosis contain an even larger amount of this enzyme (Fig 8) Accordingly, in vitro human HepG2 cells and HSC/MFs do express chymase at baseline, with further transcription of chymase’s gene after profibrogenic TGF-β1 (Fig 9).