Gomori trichrome, Sirius Red (Fig 1) and αSMA immunohistochemistry (Fig 2) showed liver cirrhosis with thick fibrotic septa in G3 rats, micronodular cirrhosis in rats receiving 10 mg/kg b.w. of the chymase inhibitor (G4), fibrosis with architectural distortion in rats receiving both CCl4 and the larger dose of the chymase inhibitor (G5) [30]. The gene discussed is ACTA1; the disease is cirrhosis of liver.