Our group described, in experimental cirrhosis, the diuretic and portal hypotensive effects of the acute inhibition of metallo-endopeptidase neprilysin [22, 27], which degrades the natriuretic peptide angiotensin-(1–7) into angiotensin-(1–4) [41], destroys atrial natriuretic factors and generates endothelin-1 [27]. Here, EDN1 is linked to Cirrhosis.