DNMT3A and acute myeloid leukemia: It has recently been reported that the Flt3ITD/ITD; Dnmt3af/f mice spontaneously developed a fully penetrant AML while Flt3ITD/+;Dnmt3a knockout mice had a much longer disease latency and disease spectrum.[35] This suggests that the relative allelic ratio of ITD vs. wild type FLT3 is an important factor when evaluating the disease aggressiveness in the FLT3/ITD DNMT3a knockout double-mutant mice.