A recent study in AML1-ETO driven murine leukemia illustrates the utility and power of cross referencing genomic data from murine studies with the enormous repository of publicly available data from human leukemia samples sharing the same genetic underpinnings.[33] Using a similar approach in our model, we hope to identify cooperative orthologous genomic events which we can introduce into Flt3ITD/+;Dnmt3af/f bone marrow, thereby creating an increasingly relevant model of the disease, increasing aggressiveness and facilitating in vivo TKI and epigenetic combination therapy testing. Here, RUNX1 is linked to leukemia.