TNF and cancer: In addition to epidermal renewal, IngMeb also activates Protein Kinase C -delta (PKC-δ) which has been found to induce apoptosis in cancer cell lines [10,26] and induce upregulation of neutrophil mediators, (IL-8, TNF-α, ICAM-1, and E-selectin), resulting in massive neutrophil invasion to the skin [27].