FOXO1 and neoplasm: The role of FOXO1 in tumorigenesis is further supported by findings in prostate cancer and cervical cancer.49, 50 As the role of FOXO1 protein in tumorigenesis becomes increasingly apparent, a study of direct FOXO1 activator use in EC should be considered and prospective clinical research is necessary to fully appreciate the impact of a direct FOXO1 activator on tumor regression and patient survival.