To confirm their effect on diastolic function in SCD, these five SNPs were also tested for association with E/e′, and rs11214107 (in IL18; P = 0.030) and rs9496646 (in FUCA2; P = 0.003) were also significantly associated with E/e′ with a consistent direction of effect as that observed in the eQTL analysis (Table 3). The gene discussed is IL18; the disease is Schnyder corneal dystrophy.