GH1 and colitis: Animals with colitis also exhibit pubertal delay which can be partially corrected by anti-cytokine treatment [20, 21] Growth-retarded children and adolescents with CD have a variety of endocrine profiles ranging from growth hormone resistance to growth hormone deficiency [22, 23] which reflect the impact on the somatotropic axis of cytokines, under-nutrition and sex-steroid deficiency.