TACR3 and polycystic ovary syndrome: Hitherto, NK3R antagonists have been demonstrated to suppress LH secretion in states of high LH output, such as in women with Polycystic Ovary Syndrome (26), or in the ovariectomized ewe and castrate monkeys (25, 34), and in intact female monkeys a delay of surge like, but no decrease in basal LH secretion was observed (25).