Likewise, previous observations from our laboratory have shown that the stimulation of sphingolipid synthesis de novo that triggers THC in glioma and other types of cancer cells elicits an ER stress-related pathway that leads to a TRIB3-dependent inhibition of the AKT-MTORC1 axis and the subsequent activation of autophagy.24,25. This evidence concerns the gene AKT1 and central nervous system cancer.