Specifically, data support the hypothesis that the THC-promoted modification of the sphingolipid composition of cancer cells is based on its ability to (i) stimulate sphingolipid synthesis de novo (via enhanced expression of several genes encoding enzymes of this pathway) and (ii) inhibit the transport of sphingolipids from the ER to the Golgi (at least in part via inhibition of the ceramide transporter protein COL4A3BP). This evidence concerns the gene CERT1 and cancer.