It has been recently shown that manipulation of the activity of SMPD1 (sphingomyelinase phosphodiesterase 1, acid lysosomal; a hydrolytic enzyme located primarily in the lysosomes) leads to LMP and stimulation of cancer cell death,36,42 suggesting that changes in the sphingolipid composition of lysosomes can affect the stability of this organelle. Here, SMPD1 is linked to cancer.