Nevertheless, control shRNAs targeting essential genes (Rpa1, Rpa3 and Polr2b; [26]) were consistently depleted in all four replicates, as were shRNAs targeting genes that either cooperated with Myc (Prmt5 and Odc) [15, 16] or belonged to known oncogenic pathways in Eμ-myc lymphomas (Adsl and Rsl24d1) [18, 19] (Supplementary Table S2). The gene discussed is POLR2B; the disease is lymphoma.