CXCR3 and systemic lupus erythematosus: By analyzing CXCR3 and CCR6 expression, we also interestingly described an altered phenotype of cTFH cells characterized by the enhanced frequency of B cell helper TFH2-like CXCR3−CCR6− cells and a decreased frequency of CXCR3+CCR6−TFH1-like cells (not able to provide B cell help) in lupus patients with an active disease [69].