Having found comparable results to previous studies, with regard to lower eosinophilia, lower inflammation in the lungs, and IL-10 increased production in mice infected with S. mansoni, Pacífico and colleagues [38] have shown lower levels of OVA-specific IgE in the infected mice, first report for S. mansoni, and, more importantly, have highlighted the importance of T regulatory cells in this context. This evidence concerns the gene IGHE and Increased total eosinophil count.