Our suggestion that CCR4 and CXCR3 might participate in neuroinflammation is based on previous reports associating CCR4 with recruitment of white blood cells and production of cytokines after myocardial infarction [60] and correlated CXCR3 with leukocyte accumulation in focal stroke and gliosis [61]. This evidence concerns the gene CXCR3 and Gliosis.