CXCL12 may influence vascular, astroglial, and neuronal functions via CXCR7 and mediate lymphocyte recruitment in the ischemic areas via CXCR4 after stroke, thus supporting its role in neuroinflammation [73], although it has also been reported that CXCR4 and CXCR7 participate in neurogenesis promoting migration of neural progenitors and bone marrow mesenchymal stem cells [67, 74]. This evidence concerns the gene CXCL12 and stroke disorder.