Methylglyoxal has also been found to inactivate glyceraldehyde-3-phosphate dehydrogenase (GA3PD), a key enzyme of the glycolytic pathway, and this inactivation is responsible to a significant extent for the inhibition of glycolysis of tumor cells by methylglyoxal (Halder, Ray & Ray, 1993). This evidence concerns the gene GAPDH and neoplasm.