AREG and metabolic disease: Most of the genes were linked to digestive organ tumor but eight were specifically linked to colorectal cancer namely AREG/AREGB, CD9, CEACAM1, IL8, and SLC2A3 (or GLUT3), MCM3, MT1E and MT1F. Other biological networks affected by the BLE, in descending scores, were “Cancer, Cardiac Dilation, Cardiovascular System Development and Function” (32), “Cell Cycle, Connective Tissue Development and Function, Cellular” (27), “Metabolic Disease, Drug Metabolism, Endocrine System Development” (25), and “Behavior, Cell-To-Cell Signaling and Interaction, Drug Metabolism” (21).