MAS1 and heart failure: In the same way, Zong et al. showed that rats with adriamycin-induced heart failure had low plasma levels of Ang-(1-7) and reduced expression of myocardial Mas receptor, while treatment with telmisartan and losartan restored Ang-(1-7) levels and suppressed myocardial AT1 receptor expression but did not influence the expression of Mas and AT2 receptors [78].