IGF1R and Ewing sarcoma: The first attempt of targeted therapy integration is currently being undertaken in a randomized phase II trial evaluating the addition of ganitumab (IGF-1R human monoclonal antibody) to multi-agent chemotherapy (vincristine, doxorubicin, cyclophosphamide, ifosfamide, and etoposide) for patients with newly diagnosed metastatic Ewing sarcoma (AEWS1221/NCT02306161).