Using a p value cutoff of less than 0.05, pathways in cancer, MAPK signaling, Wnt signaling, calcium signaling, chemokine signaling, insulin signaling and neurotrophin signaling, regulation of actin cytoskeleton, focal adhesion, endocytosis, protein processing in the endoplasmic reticulum, and axon guidance were the significantly enriched KEGG signaling pathways and were involved in T2DM with D-IBS (Figure 4(b)). The gene discussed is INS; the disease is type 2 diabetes mellitus.