SOD1 and colitis: Therefore, the present study aimed to investigate the antioxidant, anti-inflammatory, and immunomodulatory activities of A. adstringens ethanolic extract in a mouse model of experimental colitis induced by DSS, regarding the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), cytokine levels, and macroscopic and microscopic changes of colonic mucosa.